Stephen Poole

Biography

Dr. Poole received his Ph.D. in biology from the University of California, San Diego in 1983, where he studied the structure and regulation of the discoidin I gene family of Dictyostelium discoideum. He conducted postdoctoral research in the Department of Biochemistry and Biophysics at the University of California, San Francisco, studying the structure and functions of the engrailed segmentation gene of Drosophila. Dr. Poole joined the UCSB faculty in January 1989.

Research

I collaborate with the Low and Hayes labs on identification and analysis of several gene families involved in contact-dependent growth inhibition (CDI) in bacteria. My current focus is on identification of genes that regulate CDI loci. A second focus has been to use a combination of genetic and molecular approaches to understand how genes interact to produce complex structures during development of Drosophila. One project focuses on a genetic approach to identify genes involved in bristle formation by dominant misexpression.

Selected Publications

Wäneskog M, Halvorsen T, Filek K, Xu F, Hammarlöf DL, Hayes CS, Braaten BA, Low DA, Poole SJ, Koskiniemi S. (2021) Escherichia coli EC93 deploys two plasmid-encoded class I contact-dependent growth inhibition systems for antagonistic bacterial interactions, Microb Genom. 2021 Mar;7(3):mgen000534

Prokchorchik M, Pandey A, Moon H, Kim W, Jeon H, Jung G, Jayaraman J, Poole S, Segonzac C, Sohn KH, McCann HC. (2020) Host adaptation and microbial competition drive Ralstonia solanacearum phylotype I evolution in the Republic of Korea, Microb Genom. 2020 Nov;6(11):mgen000461

Koskiniemi S, Garza-Sánchez F, Edman N, Chaudhuri S, Poole SJ, Manoil C, Hayes CS, Low DA (2015) Genetic analysis of the CDI pathway from Burkholderia pseudomallei 1026b, PLoS One, 10(3):e0120265

Koskiniemi S, Garza-Sánchez F, Sandegren L, Webb JS, Braaten BA, Poole SJ, Andersson DI, Hayes CS, Low DA (2014) Selection of orphan Rhs toxin expression in evolved Salmonella enterica serovar Typhimurium, PLoS Genet, 10, e1004255

Hayes CS, Koskiniemi S, Ruhe ZC, Poole SJ, Low DA (2014) Mechanisms and biological roles of contact-dependent growth inhibition systems, Cold Spring Harbor Perspect Med, 4, a010025

Lim YW, Schmieder R, Haynes M, Furlan M, Matthews TD, Whiteson K, Poole SJ, Hayes CS, Low DA, Maughan H, Edwards R, Conrad D, Rohwer F (2013) Mechanistic model of Rothia mucilaginosa adaptation toward persistence in the CF lung, based on a genome reconstructed from metagenomic data, PLoS One. 8: e64285

Schaub RE, Poole SJ, Garza-Sánchez F, Benbow S, Hayes CS (2012, Proteobacterial ArfA peptides are synthesized from non-stop messenger RNAs, J Biol Chem. 287:29765-75

Nikolakakis K, Amber S, Wilbur JS, Diner EJ, Aoki SK, Poole SJ, Tuanyok A, Keim PS, Peacock S, Hayes CS, and Low DA (2012) The toxin/immunity network of Burkholderia pseudomallei contact-dependent growth inhibition (CDI) systems, Mol Microbiol, 84, pp. 516-529

Poole, SJ, Diner, EJ, Aoki, SK, Braaten, BA, de Roodenbeke, C, Hayes, CS, and Low, DA (2011) Identification of functional toxin/immunity genes linked to contact-dependent growth Inhibition (CDI) and rearrangement hotspot (Rhs) systems, PLOS Genetics, 7: e1002217

Aoki SK, Poole SJ, Hayes CS, and Low DA (2011) Toxin on a stick: Modular CDI toxin delivery systems play roles in bacterial competition, Virulence, 2, pp. 356-359

Aoki SK, Diner EJ, de Roodenbeke CT, Burgess BR, Poole SJ, Braaten BA, Jones AM, Webb JS, Hayes CS, Cotter PA, Low DA (2010) A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria, Nature, 468, pp. 439-442

Cheli VT, Daniels RW, Godoy R, Hoyle DJ, Kandachar V, Starcevic M, Martinez-Agosto JA, Poole S, DiAntonio A, Lloyd VK, Chang HC, Krantz DE, Dell'Angelica EC (2010) Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency, Hum Mol Genet, 19, pp. 861-878